"Blood on their hands"
In act two scene two they mention the blood on Macbeth's hands. The blood on Macbeth's hands is referring to their murderous journey they have been on. The blood is a symbol of guilt, and they feel as though the crimes they have committed has marked them in a way that can't be washed away. An example for this would be in line 58 "Will all great Neptune's ocean wash this blood clean from my hands?"
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